Estimation Of Sera Levels Of Urea, Uric Acid and Creatinine in Oral Submucous Fibrosis (OSMF) Patients: A Randomized, Blind trial, A Preliminary Study

Aim: To analyze serum uric acid, urea, and creatinine levels in Oral Submucous Fibrosis patients and compare them with those of healthy controls. Materials and Methods: 40 OSMF patients and 20 controls had serum uric acid, urea and creatinine levels measured using spectrophotometer. The data obtained was analyzed using the Statistical Package for the Social Sciences, version 19.0 (SPSS 19). Statistical significance was determined at p < 0.001. Results: No significant variation was observed in serum uric acid and urea levels although the results were found to be significant in case of sera creatinine levels in OSMF patients when compared with normal controls. Conclusion: This study showed that serum uric acid, urea and creatinine were altered in OSMF patients compared with healthy volunteers but were statistically insignificant, not for creatinine. However, further prospective cohort studies are suggested to better understand their role in the etio-pathogenesis of OSMF. Received date: 09/10/2015 Accepted date: 15/10/2015 Published date: 22/10/2015